eLife1d
Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research
A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
eLife1d
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and ...
eLife2d
The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting
A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.
eLife4d
Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation
We show that pharmacological elevations of noradrenergic but not glucocorticoid activity after retrieval impair subsequent remembering. These impairments were bound to strong hippocampal and cortical ...
eLife3d
Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction
This study presents valuable findings from an observational dataset in a riverine ecosystem about the effects of genetic and species diversity, across multiple trophic levels, on ecosystem functions.
eLife2d
Reprogramming: A perfect recipe for a corticospinal neuron
A tailored cocktail of genes can reprogram a subset of progenitors to no longer produce glial cells and instead develop into neurons involved in motor control.
eLife4d
Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells
The raw mass spectrometry data was deposited in the PRIDE repository:Project Name: Spatially restricted proteomics reveals dynamic changes in the caveolin-1 interactome in response to increased membra ...
eLife4d
Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice
However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. We investigated how Cb-tDCS affects the firing rate of ...
eLife2d
Celebrating 10,000 submissions
Hear from authors about their experiences publishing with eLife, and how you can get involved in changing research communication.
eLife8d
Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory
Department of Psychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Laboratory of Neuroinformatics, Nencki Institute of Experimental Biology o ...
eLife8d
NMDA receptor antagonist memantine selectively affects recurrent processing during perceptual inference
Perceptual inference requires the integration of visual features through recurrent processing, the dynamic exchange of information between higher and lower level cortical regions. While animal ...
eLife12d
Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation
For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.