The EMBO Journal9h
Correction of a widespread bias in pooled chemical genomics screens improves their interpretability
A widespread artifact in bacterial chemical genomics caused by uncorrected differences in growth causes spurious correlations ...
The EMBO Journal10h
Cancer cell-intrinsic biosynthesis of itaconate promotes tumor immunogenicity
The Krebs cycle byproduct itaconate regulates immune cell function, however its role within tumor cells remains unclear. Here ...
The EMBO Journal12h
p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb
Fibrosis and accumulation of senescent cells are common tissue changes associated with aging. Here, we show that the CDK ...
The EMBO Journal12h
Cellular senescence, p21, and the path to fibrosis
In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...