A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and ...

A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.

Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue ...

We show that pharmacological elevations of noradrenergic but not glucocorticoid activity after retrieval impair subsequent remembering. These impairments were bound to strong hippocampal and cortical ...

This study presents valuable findings from an observational dataset in a riverine ecosystem about the effects of genetic and species diversity, across multiple trophic levels, on ecosystem functions.

A tailored cocktail of genes can reprogram a subset of progenitors to no longer produce glial cells and instead develop into neurons involved in motor control.

However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. We investigated how Cb-tDCS affects the firing rate of ...

Hear from authors about their experiences publishing with eLife, and how you can get involved in changing research communication.

The raw mass spectrometry data was deposited in the PRIDE repository:Project Name: Spatially restricted proteomics reveals dynamic changes in the caveolin-1 interactome in response to increased membra ...

Computational principles shed light on why movement is preceded by preparatory activity within the neural networks that control muscles.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, China Department of Endodontics, West China ...