The Patriots could be without a pair of their best defenders on Sunday afternoon in San Francisco.

Outside linebacker Anfernee Jennings (shoulder) was upgraded from a non-participant to limited. Getting Jennings back on early downs against the 49ers’ stout rushing attack would be big for the Patriots’ defense.

On Sunday, the New England Patriots will face arguably the toughest opponent on their 2024 regular season schedule. They’ll be on the road at Levi’s Stadium for a clash with the defending NFC champion San Francisco 49ers.

Both the New England Patriots and the San Francisco 49ers saw the return of key players as they prepare for their Week 4 matchup at Levi’s Stadium on Sunday.

Here are five keys the 49ers (1-2) must accomplish to avoid losing a third straight game Sunday when they host the New England Patriots (1-2).

Losing to the Los Angeles Rams was a gut punch to the San Francisco 49ers.  That was a game that had victory written all over it for them. Instead, they collaps

The San Francisco 49ers are back at their fortress, Levi's Stadium, to take on the New England Patriots. This return home carries immense significance as the 49ers are determined to snap a two-game losing streak and reclaim their winning form.